The post holder will be responsible for aiding in running a patient-derived immune xenograft (PDiX) core within the Centre and under the supervision of Dr. Shah and Prof Quezada and relevant members of the team. The goal of the core is to explore methods for the generation of ‘immune competent’ PDX models and in vitro explants for the use in the evaluation of current and novel immunotherapy agents and combination therapies. The post holder will work with member the CRUK CoL centre to establish the relevant SOPs for establishment of these models including sample procurement, processing, implantation and analysis. In addition the post holder should have expertise in human tissue handling (HTA), cell culture techniques and analysis including high dimensional flow cytometry, histology, and PCR. The post holder will also contribute to experimental design and analyses using newly developed PDX models.
The candidate is required to design and carry out laboratory projects under the guidance of the supervisor, assist in the development of new protocols as they become relevant for the project, maintain an ongoing knowledge of the relevant scientific literature and advancements in the field, collaborate with and/or supervise other laboratory staff as appropriate, to attend research seminars and other departmental meetings as required and to to be aware of and act upon:
Disciplinary procedure and Disciplinary rules
Section 7 and 8 of the Health and Safety at Work Act
Departmental Fire Guidelines
Equal Opportunities Policy
To comply with the Health & Safety regulations of the department.
The post is funded until the 31/03/2022 in the first instance.